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Tolerability, safety and pharmacodynamics of oral, small-molecule glucagon-like peptide-1 receptor agonist danuglipron for type 2 diabetes: a 12-week, randomized, placebo-controlled, phase 2 study comparing different dose-escalation schemes
The gut-brain axis the bidirectional communication network between the gastrointestinal tract and central nervous systemrepresents another theoretical consideration
GLP-1s diabetes benefits include substantial A1C reductions (typically 1-1.5% or more), low hypoglycemia risk due to glucose-dependent mechanism, weight loss rather than weight gain (unlike insulin and many other diabetes medications), cardiovascular protection demonstrated in outcome trials, and potential slowing of disease progression by preserving beta cell function
Upper limit of normal for ACR 2 mg/mmol vs 3 mg/mmol, the threshold between A1 and A2 for people with diabetes The threshold at which an ACR should be considered abnormal is controversial
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