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As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

2018;362 doi: 10.1136/bmj.k3760

For GI-specific applications, BPC-157 has been studied in two human trials for ulcerative colitis and multiple sclerosis, with no reported toxicity and an LD1 (lethal dose) that was never achieved in preclinical models

The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

Spencer A, Horvath N, Gibson J, Prince HM, Herrmann R, Bashford J, Joske D, Grigg A, McKendrick J, Prosser I, Lowenthal R, Deveridge S, Taylor K

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