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Patients with fibromyalgia

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A5 is similar to dipeptide WY, while B16 features a KFY structure, suggesting that C-terminal tyrosine residues play an important role in the tyrosinase inhibition

Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of MTC or MEN2), and warnings regarding pancreatitis, gallbladder disease, and severe gastrointestinal disease