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doi: 10.1126/scitranslmed.aaa9853 97 ShiLSunZSuWXuFXieDZhangQet al

In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models

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Common side effects include nausea, diarrhea, vomiting, constipation, stomach discomfort, rash or pain around the injection site, fatigue, burping, hair loss, and gastroesophageal reflux disease