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Agmatine, a metabolite derived from L-arginine and an endogenous polyamine, is primarily produced by the metabolism of intestinal flora such as Escherichia , Bacteroides , and Enterobacteriaceae [58]

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Afferent vagal fibers detect cytokines, microbial metabolites, and LPS and send signals to the nucleus tractus solitarius (NTS) in the brainstem [119]

ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

10.1158/0008-5472.Can-20-1692 22 CasolinoR.BiankinA