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The two Phase 3 trials of the higher-dose version compared the efficacy and safety of once-weekly semaglutide 7.2mg to semaglutide 2.4mg over 72 weeks and showed that individuals with obesity, with or without type 2 diabetes, lost around 3 percent more of their body weight

Most resolve within 4-6 weeks

Our Michigan-based approach goes beyond simple prescription management

That risk increases with age and with heavy smoking and is significant in women over 35, who should not use combined oral contraceptives

Herskowitz: The oldest woman in the world was smoking a cigar every day and drinking, uh, you know, having alcohol every night

To scale or not to scale: the principles of dose extrapolation