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Phase 1: Retatrutide foundation (weeks 1-8) During this initial phase, the goal is to establish retatrutide tolerance before adding cagrilintide

Availability of data and materials The material supporting the conclusion of this review has been included within the article

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The membranes were blocked for 1 h at room temperature with 5% w/v nonfat dry milk solution, followed by incubation with primary antibodies against p53 (1:1,000) and -actin (1:5,000) at 4C overnight

The body interprets rapid fat loss as a significant stressor, releasing inflammatory mediators as part of the adaptive response