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In numerous studies, it has been shown that hydroxocobalamin remains active in the body for much longer and is absorbed by the cells much more effectively which is why it can be administered less frequently

The spray format may offer advantages for those who prefer sublingual delivery or have difficulty swallowing capsules

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Blood in stool Fever Dehydration causing dizziness, dark urine, or dry mouth Diarrhea lasting more than 2 days without improvement

In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity