Bertini, E
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These approaches have led to significant weight loss with the dual GLP-1/glucagon receptor agonist survodutide (-13.5% with the 6-mg dose at 76 weeks in a phase 3 SYNCHRONIZE-1 trial) [16] , the dual GLP-1 receptor agonist and GIP antagonist Maridebart cafraglutide (known as MariTide) (-12.3% to -16.2% across different doses at 52 weeks in a phase 2 trial) [17] or the triple GLP-1/GIP/glucagon receptor agonist retatrutide (-24.2% with the 12-mg dose at 48 weeks in a phase 2 trial) [18]
Still, the studys scale, duration and granular clinical data provide meaningful evidence to inform riskbenefit discussions. Balancing risks and benefits Importantly, the analysis assessed risk associated with initiation of semaglutide rather than cumulative dose or treatment duration. Whether risk varies by dosing intensity or length of exposure remains an open question
Leishear K, Boudreau RM, Studenski SA, et al
