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Key Safety Monitoring: Regular assessment for pancreatitis symptoms (severe abdominal pain) Monitoring for gallbladder disease in patients with risk factors Thyroid surveillance with annual TSH and symptom assessment Blood glucose monitoring if concurrent diabetes medications are used Future Directions and Research Emerging research on GLP-1-estrogen conjugates shows promise for even more targeted therapy in menopausal women

Niacinamide has been shown to reduce inflammation in various models, potentially through inhibition of NF-kappaB signaling and modulation of immune cell function

Higher doses slow gastric emptying more aggressively, which means more constipation

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