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The STEP Trials (Ozempic/Wegovy) In the STEP 1 trial, participants on semaglutide 2.4 mg lost an average of 14.9% of body weight over 68 weeks

Muscle pain and body aches (mildly worse) Muscle pain on tirzepatide may be slightly worsened by alcohol through increased inflammation and dehydration

In addition, there was a statistically significant decrease in biomarkers used to track oxidative stress such as 8-isoprostane and ratio of GSSG to GSH

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These insights may help support discussions with your provider about whether GLP-1 is a good fit and which formulation or dose strategy might align with your genetic profilethough they don't predict exact outcomes

This shift is especially visible in performance-focused categories, where cognitive enhancements are becoming a defining factor of perceived product value rather than a niche benefit