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Although body size is one of innumerable factors entwined with the development of chronic disease, it is not a reliable indicator of health and should not be the focus of treatment

Light stomach discomfort or nausea

The more recent semaglutide trials (ADJUST T1D) reported up to 30% insulin dose reduction alongside weight loss and improved time in range

They are tightly controlled by mitochondrial dynamics and mitophagy (Rahman et al., 2022)

Likelihood score: B (likely cause of clinically apparent liver injury)

Moreover, excess weight can strain joints, leading to conditions such as osteoarthritis and exacerbating respiratory issues including obstructive sleep apnea