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( Peptide InnOvatioN for the Early diabetEs tReatment (PIONEER) trial showed that GLP-1RAs caused an overall nausea rate of 15-20% and were associated with gastrointestinal adverse events, but these were temporary and dose-dependent ( Underlying mechanism The mechanisms that contribute to the beneficial effects of SGLT2i and GLP-1RAs in patients with T2DM have been extensively studied

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4 Glucagon-like peptide-1 receptor agonists in type 1 diabetes Glucagon-like peptide-1 (GLP-1) is secreted in response to food consumption from intestinal L-cells