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J Aging Res 2013:951786

Weight loss and biology: Rapid weight loss itself can have psychological effects

It is also associated with endocrine system disorders

Hormones and enzymes: Naturally occurring hormones and enzymes support digestion, metabolism, and appetite regulation, including GLP-1, involved in satiety signaling

Beyond routine glucose and lipid panels, endocrine studies increasingly include microbiome profiling, bile-acid pools, and hepatokine/adipokine panels (FGF21, adiponectin) to explain shifts in substrate preference