Here's a table of the top 10 most problematic homozygous SNPs, their triggered cytokines/markers, and associated diseases/symptoms (based on clinical observations and genetic data): Table: Top 10 Genetic "Arsonists" and "Anchors" from the Purser Model Homozygous SNPs Driving Undiagnosable Inflammation These SNPs (e.g., from MTHFR, CBS, IL6) are common culprits, often homozygous in our patients
Moreover, various specialized pro-resolving mediators (SPMs) produced from omega-3 PUFAs help in moderating undue neuroinflammatory responses and inflammatory pain, facilitating communication between glial cells and neurons
M., Tozzi, G., Federici, G
Li D, Gu X, Lu L, Liang L (2010) Effects of phenylalanine on the survival and neurite outgrowth of rat cortical neurons in primary cultures: possible involvement of brain-derived neurotrophic factor
In: Sweeney, A.D., Wanna, G.B., Carlson, M.L., Perkins, E.L
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action