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Participants completed original and adapted forms of validated assessments (see Supplemental document)

For lean individuals or anyone concerned about muscle penetration, the 45-degree angle combined with a skin pinch provides the maximum margin of safety

Take slow, deep breaths in through your nose and out through your mouth

Hypersensitivity Reactions: Common side effects include urticaria, anaphylactoid reactions, angioedema, and anaphylaxis

The active product and corresponding placebo product were visually identical to maintain masking of participants and site staff

In obesity patients in SURMOUNT3 and SURMOUNT4, a high rate of AEs of 87.1% and 81.0%, respectively, was observed, also with GI AEs being the most frequent system affected