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Quick Answer: Tirzepatide is not metabolized by CYP450 enzymes When starting tirzepatide, most clinicians cut the patients mealtime (prandial) insulin dose by 20 to 30% as a starting point, with further adjustments based on glucose monitoring over the first 1 to 2 weeks

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Cortisol helps show how your body is handling the stress of a new medication and caloric changes

Initial data in the US show that the most affected categories for GLP-1 users are: Processed Foods and Snacks: declines of about 5-10% in snacks, sweets, and ultra-processed items

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