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Emerging neuroscience literature in Nature Mental Health highlights the bidirectional relationship between metabolic regulation and neuropsychiatric symptoms

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Melanotan I (MT-1) is a linear first-generation alpha-MSH analogue studied for more selective melanocortin activity, whereas Melanotan II is a cyclic analogue studied for broader melanocortin receptor activity

In addition, IL-4 / mice had decreased production of tumor necrosis factor , CXCL1 and interleukin-1 in the liver, but not in a remote site such as the lungs