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Incubations were carried out using equimolar amounts of AX and the thiol functional-reagent or nonthiol antioxidant, in phosphate buffer saline (PBS) at 37C for 24 h and lyophilized

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In addition, supplementation with ursodeoxycholic acid (UDCA) elicited a reduced body weight gain similar to that by CA supplementation

Mechanistically, it was revealed that glutamine uptake effectively increased the concentration of tumor glutamine and its downstream metabolite -KG, which drove hypomethylation of H3K4me3 via JmjC-containing KDMs, resulting in the downregulation of epigenetically activated oncogenic pathways [89]