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Later in 2014, with the support of Food and Drug Administration (FDA) and European Medicines Agency (EMA), the PSTC included neutrophil gelatinase-associated lipocalin (NGAL) and osteopontin (OPN) for further evaluation as emerging biomarkers (Dieterle et al

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Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome

CHAC1-mediated GSH degradation in the matrix supports FeS cluster proteins and electron transport ( via two convergent mechanisms: the direct depletion of glutathione and the indirect facilitation of mitochondrial ROS production, thereby coupling sustained metabolic activity to ferroptotic cell death under cysteine limitation