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Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: final overall survival results from SOLAR-1

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Cell culture studies indicated that the vitamin E ester, -tocopheryl succinate, could inhibit proliferation and induce apoptosis in a number of cancer cell lines (13)

220 While IRE1 and ATF6 upregulate HRD1, prolonged ER stress downregulates bifunctional apoptosis regulator (BAR), which is known to mediate proteasomal degradation of the ER-resident IRE1 inhibitor protein Bax inhibitor-1 (BI-1), which controls IRE1 signaling

doi: 10.1002/jcp.30468 14 ZhangTXiQSWangDLiJJWangMLiDet al