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The most significant challenge is the complete absence of pharmacokinetic data

It has been suggested that exaggerated the expression of human islet amyloid polypeptide (hIAPP) in T2D is implicated in the pathogenesis of AD

"We ask the question, do we need to change the dose

The drug is metabolized primarily through proteolytic cleavage and does not undergo hepatobiliary excretion as an intact molecule

SYNERGY-NASH: Tirzepatide and metabolic steatohepatitis (MASH) SYNERGY-NASH (Loomba et al., NEJM 2024, NEJMoa2401943, PMID 38856224) is a phase 2 trial in 190 patients with metabolic steatohepatitis (MASH) and biopsy-proven stage 2 or 3 fibrosis

This is particularly important for medications with a narrow therapeutic index or those requiring rapid onset of action