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Firstly, the differences in metabolic preferences among different tumor subclones, such as glycolytic dependent type and oxidative phosphorylation-dominated type, lead to the failure of a single metabolic intervention strategy [138]

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2 Review of bariatric and metabolic surgeries Bariatric surgery remains the most effective long-term treatment for morbid obesity type-2 diabetes and metabolic syndrome, with recent updates expanding eligibility and improving safety and outcomes ( 2.1 Sleeve gastrectomy (SG) Sleeve gastrectomy (SG) is one of the most commonly performed bariatric surgical procedures aimed at inducing body mass loss and improving metabolic profile in patients with morbid obesity