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For systemic research, it must be administered via subcutaneous or intramuscular injection to bypass the digestive tract and ensure bioavailability

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The upper result, plus the evidence that the ratio of IL18R1/CXCR3 is six fold more in the ovary than in the tumor, supports that IL18R1 is surplus and CXCL10 can directly bind to IL18R1 (Supplementary Fig

doi: 10.1073/pnas.042707999 75 EmanueleS.CelesiaA.DAnneoA.LauricellaM.CarlisiD.De BlasioA.et al

Advances in Therapy, 39 (6), 2452-2467

These mechanisms may help explain why the peptide is frequently referenced in research involving regenerative and recovery-related models