In the diabetes TRIUMPH-2 trial, reported side effects included: Diarrhea (around 27 to 34 percent of participants, depending on the dose) Nausea (14 to 28 percent) Constipation (14 to 17 percent) Decreased appetite (6 to 17 percent) Vomiting (6 to 16 percent) In the TRIUMPH-3 trial for adults with severe obesity and heart disease, participants reported: Diarrhea (around 24 to 30 percent of participants, depending on the dose) Nausea (22 percent) Constipation (16 to 18 percent) Decreased appetite (14 to 15 percent) Hyperglycemia, or high blood sugar (3 to 4 percent) The high rates of diarrhea surprised Ali
Menstrual irregularities, such as missed periods, heavier or lighter bleeding, or changes in cycle length, can be a concern for women taking semaglutide
It may itch or tickle but shouldnt feel painful
[1] This discomfort is usually transient and can be minimized by using proper technique and allowing the solution to come to room temperature before injection
For milder or occasional symptoms, over-the-counter antacids (calcium carbonate, magnesium hydroxide) can provide rapid but temporary relief
A Reuters review last year found that the US Federal Drug Administration had received 265 reports of suicidal thoughts or behaviour in patients taking semaglutide or similar medicines since 2010
