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Glutamate may also induce intra-articular inflammatory responses and abnormal pain in OA patients by activating N-methyl-D-aspartic acid (NMDA) receptors, further advancing OA progression (Piepoli et al., 2009)

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As can be seen, MAHT at a dose of 4 mg induced a significant increase in GPx enzyme activity (approximately 130 %), with no increase in the other parameters, after the treatment with ozone therapy

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