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doi: 10.1016/j.biopha.2019.109537 19 HelmstadterJ.FrenisK.FilippouK.GrillA.DibM.KalinovicS.et al

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1) Volume loss (the deflated look) Common areas: temples, midface, under-eye hollowness, around the mouth, jawline

Exenatide improves excessive daytime sleepiness and wakefulness in obese patients with type 2 diabetes without obstructive sleep apnoea

However, the bodys naturally produced GLP-1 has a very short half-life, lasting only a few minutes before it is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4)