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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]

Clinical studies suggest that 2501000 mg daily can provide significant benefits

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For GI applications, oral delivery that reaches the gut mucosa before systemic absorption is often preferable to injectable systemic delivery

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