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Parallel reaction monitoring (PRM) acquisition improved specificity with MS 2 acquisition The Stellar MS boosts measured signal-to-noise (S/N) ratios 3X at 0.05 pg/mL GLP-1 spiking levels through co-adding multiple MS 2 product ion signal without adding noise

Abbreviations ABC ATP-binding cassette ABCB1 ATP-binding cassette subfamily B member 1 ABCC2 ATP-binding cassette subfamily C member 2 ADRs adverse drug reactions APOE apolipoprotein E ATP adenosine triphosphate AUC area under the concentrationtime curve CACNA1S calcium voltage-gated channel subunit alpha 1S CK creatine kinase CLCN1 chloride channel protein 1 COQ 10 coenzyme Q 10 COQ 2 coenzyme Q 2 CPIC Clinical Pharmacogenetics Implementation Consortium CYP450 cytochrome P450 deQTL differential expression quantitative trait loci eQTL expression quantitative trait loci EYS eyes shut homolog FDA Food and Drug Administration GATM glycine amidinotransferase gnomAD genome aggregation database GoDARTS Genetics of Diabetic Audit and Research GWAS genome-wide association studies HLA human leukocyte antigen HLA-DRB1 human leukocyte antigen DR-isotope beta chain HMG-CR hydroxymethylglutaryl-coenzyme A reductase HTR3B 5-hydroxytryptamine receptor 3B HTR7 5-hydroxytryptamine receptor 7 JUPITER Justification for the Use of Statins in Primary Prevention, An Intervention Trial Evaluating Rosuvastatin LARGE glycosyl transferase-like protein LDL low-density lipoprotein LILRB5 leukocyte immunoglobulin-like receptor subfamily B5 OR Odds ratio PCSK9 proprotein convertase subtilisin/kexin type 9 PD pharmacodynamics PK pharmacokinetics PRIMO Prediction of Muscular Risk in Observational Conditions PRS polygenic risk score RYR1 ryanodine receptor 1 RYR2 ryanodine receptor 2 SIM statin-induced myotoxicity SLC solute carrier SLCO1B1 solute carrier organic anion transporter family member 1B1 SNPs single nucleotide polymorphisms SR sarcoplasmic reticulum SRM statin-related myotoxicity UGT uridine 5 -diphospho (UDP)-glucuronosyltransferase ULN upper limit normal VDR vitamin D receptor