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PlexusDx Precision Peptide Genetic Test maps 49 peptides across 14 metabolic pathways, including genes that regulate energy production (GIPR rs1800437, GLP1R rs6923761) and mitochondrial function
On the other hand, and seemingly paradoxically in rats the CB1R agonist WIN 55,212-2 enhanced the anorexigenic effects of subthreshold doses of the GLP1-RA exendin-4 resulting in a significant decrease in food intake and body weight in rats [61]
While the FDA approved doses of 0.5 mg and 1.0 mg for diabetes management, the agency has also issued warnings about potential risks including pancreatitis, thyroid cancer concerns based on animal studies, and other serious adverse events