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When given orally, vitamin C concentration in human plasma is tightly controlled by multiple mechanisms acting together: intestinal absorption, tissue accumulation, renal reabsorption and excretion, and potentially even the rate of utilization

Allen LH, Hampel D, Shahab-Ferdows S, et al

Almost everyone experiences side effects such as fatigue, irritability, and difficulty concentrating during fasting periods especially at the beginning

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[49] Giorgi VS, Da Broi MG, Paz CC, Ferriani RA, Navarro PA