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Overall, 80% of people who got the oral drug reported gastrointestinal problems, which were described as mild to moderate, compared with 46% of people in the placebo group

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Probiotics and Prebiotics A healthy gut microbiome supports optimal L-cell function and hormone production, including GLP-1

Semaglutide works by mimicking the effects of a hormone called GLP-1, which helps regulate appetite and food intake

In the phase 2 obesity trial, these heart-rate changes were reported as peaking during the study and then declining later