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The contraindications for Semaglutide include: diabetic retinopathy (eye damage resulting from diabetes) impaired kidney function thyroid cancer family history of medullary thyroid carcinoma kidney disease (/w likely reduction in kidney function) pancreatitis (inflammation of the pancreas) low blood sugar multiple endocrine neoplasia (type 2)

Also, while it's shocking for anyone to develop NAION, this is not a common side effect

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NAC: Which Antioxidant Is Best for Your Liver

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Annu Rev Neurosci 46(1):101121 Prydz A et al (2020) Pro-inflammatory role of AQP4 in mice subjected to intrastriatal injections of the parkinsonogenic toxin MPP+