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DISCOVERY OF GLP-1 AND DEVELOPMENT OF INCRETIN-BASED DRUGS GLP-1 has long been identified and validated as a biomarker peptide for satiation and satiety under physiological conditions [29,30]

Most physicians know that behavioral intervention alone has limited long-term efficacy for patients with BMI over 30

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They are optimal for their insulinotropic effect exclusively when glucose levels are elevated, thereby providing the capacity to decrease plasma glucose while mitigating the risk of hypoglycemia