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Release of cathepsin B in cytosol causes cell death in acute pancreatitis

Most researchers use cycling protocols (4-6 weeks on, 2-4 weeks off) rather than continuous use

One of the most important cellular housekeeping and prosurvival pathways is macroautophagy, hereafter named autophagy, whose main action is to remove damaged proteins/organelles and generate molecules that sustain cellular core metabolism

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Since then, thousands of patients across the United States have received oral methylene blue for numerous indications

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