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EC 6.3.2.2), composed of a GCL catalytic subunit (GCLC) and GCL modifier subunit (GCLM), is the rate-limiting enzyme in GSH biosynthesis, and is responsible for converting glutamine and cysteine to -glutamylcysteine (13)

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Enucleation, a rate-limiting step of erythrocyte maturation, is tightly regulated via coordination of multiple transcription factors (FOXO3, E2F2, etc.), miRNAs (miR-30a, miR-191, miR-181a), cytoskeleton proteins (F-actin, dynein, tropomodulin, etc.), and kinases (p38 MAPK, p38 mitogen-activated protein kinase) [33]

Anti-inflammatory effect BPC 157 has significant anti-inflammatory activity and can inhibit the release of pro-inflammatory cytokines (such as TNF-, IL-6), thereby alleviating the inflammatory response

PE-22-28: PE-22-28 has limited safety data from preclinical studies

cDNA was synthesized using the Transcription First-Strand cDNA Synthesis Kit (Roche Diagnostics, Basel, Switzerland