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Epub 2017 Sep 1

cid=53375 (22 December 2025, data last accessed)

Storage and transport concerns GLP-1 medications are temperature-sensitive proteins

Strengths of the present meta-analysis are the inclusion of all CVOTs published by 10 December 2021, the very large number of participants, the high quality of the trials which minimizes the risk of bias, and the absence of significant heterogeneity in most analyses, which ranged from absent to low or moderate

The gastrointestinal effects typically emerge during dose escalation and may diminish with continued use as physiologic adaptation occurs