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A major obstacle is the difficulty of selectively targeting disease-relevant astrocyte subpopulations in the absence of well-defined marker proteins and robust methodologies against spatially restricted areas in various states in the disease progression (Liddelow et al., 2017

Patient education, careful dose titration, and close monitoring will be crucial

You're not creating a dangerous interaction, but you're reducing glutathione bioavailability by 3040%

The ALS drug failed its Phase III PHOENIX trial and could not improve scores on the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale at 48 weeks versus placebo, while falling short of its secondary endpoints

YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4

van den Heuvel JK, et al