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Collectively, flavonoids mitigate oxidative damage in epilepsy through a variety of antioxidant mechanisms, including free radical scavenging, enhancing endogenous defenses, regulating antioxidant enzymes, and preventing oxidative stress-induced conditions like ferroptosis

Indeed, a rise in IGF-1 levels have been observed in multiple studies of IGF-1R blockade, which is attributed to the reduction in IGF-1-mediated inhibition of GH secretion 26,40