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The intervention showed significant effects, with the EPA group experiencing fewer monthly migraine days, reduced usage of headache medication, and improvements in headache severity (VAS score), disability (MIDAS score), anxiety and depression (HADS score), and quality of life (MSQ score)

The mechanisms of lipotoxicity involve several cellular processes, such as ER stress, mitochondrial dysfunction and lysosomal permeabilization, ultimately leading to cell death (apoptosis, necroptosis or pyroptosis)

Carnosine is a dipeptide that scavenges free radicals, stabilizes membranes, and slows cellular aging in germ cells

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It facilitates excretion from cells (Hg), facilitates excretion from body (POPs, Hg) and directly neutralizes (POPs, many oxidative chemicals)