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Glucose is a substrate for lipogenesis, and either dietary intake of glucose and fructose or hyperglycemia due to T2DM-associated insulin resistance can lead to hepatic de novo lipogenesis

Compared to the SMBG levels in the Met+Sita group, the Sita+Acarb group demonstrated higher values at all time points at week 16

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This rigorous process ensures medications meeting approval standards have undergone substantial clinical validation before patient access

The conservative schedule extends this to 18 to 24 weeks with 6-week intervals between dose increases