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Animals were included in the study if they met the following criteria: healthy, male rats of the specified strains, with no signs of illness or physical abnormalities

Hepcidin-induced reduction in iron content and pgc-1 Expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis

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potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

PMID 26614889

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