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However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

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A 2003 mouse study specifically on Epitalon reported that treatment did not influence mean lifespan in female Swiss-derived SHR mice, though there were effects on chromosomal aberrations, estrous function, and spontaneous tumor incidence

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What's Happening: NAD+ restoration begins affecting mitochondrial function

Insertion of a lysosomal enzyme cleavage site into the sequence of a radiolabeled neuropeptide influences cell trafficking in vitro and in vivo