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This is a warning for all practitioners, as antibiotics may be overused in advanced skin tumors. Though limited by its retrospective design, the study reinforces a call for prospective trials examining microbiota modulation strategiessuch as antibiotic stewardship, bacterial profiling, or even microbiome restorationto enhance ICI outcomes

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More than 4,000 chemicals have been identified in tobacco smoke of which at least 43 are known to cause cancer in humans and animals