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[110] Immediate-release formulations have higher potential for abuse via insufflation (snorting) or intravenous injection due to a more favorable pharmacokinetic profile and easy crushability (especially tablets)

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10.2174/092986712800167392 52 PantziarkaP.SukhatmeV.CrispinoS.BoucheG.MeheusL.SukhatmeV

The significance of this topic is underscored by the increasing prevalence of obesity and type 2 diabetes worldwide

That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation

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