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Their absorption and effectiveness are also subjects of ongoing scientific debate

These findings suggest that VDR not only supports structural protein maintenance but also mitigates inflammatory damage to the barrier by suppressing Wnt/-catenin and NF-B signaling pathways [225]

It can promote tissue repair, reduces inflammation, enhances angiogenesis (new blood vessel formation), and remains stable in gastric juice enabling effective oral administration

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Therefore, a deeper understanding of the pathophysiological mechanisms of OA is crucial for the development of novel therapeutic approaches [9]

Reactive oxygen species (ROS) are essential to biological functions [5, 6]