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In metabolic tissues, especially adipose tissue, macrophage-derived ROS, advanced glycation end-products (AGEs), which are proteins or lipids that undergo glycation when exposed to sugars, leading to the formation of potentially harmful end-products, interact with the receptor for advanced glycation end-products (RAGE), and insulin resistance-induced mitochondrial overload in -cells drive systemic oxidative stress and dyslipidemia, contributing to endothelial dysfunction and atherosclerosis (6669)

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Low-dose doxycycline, minocycline, or tetracycline taken for several weeks can clear resistant cases

Storage 4C, sealed storage, away from moisture * In solvent : -80C, 2 years