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Under conditions of oxidative stress, TFAM mediates the synergistic activation of both the cGAS-STING pathway and NLRP3 inflammasomes in response to mtDNA [169]

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This fact can be used for therapeutic use of this route for substances like glutathione that are poorly absorbed from the gastrointestinal tract

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting notch signaling

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