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These symptoms are often the reasons why patients stop their treatment

What New Trials Suggest About Pain and Mobility May 11, 2026 Articles, Bone & Joint, GLP- 1 Agonist Therapy Center, GLP-1 Agonist Therapy Center, Obesity, Obesity, Therapies, Type 2 Diabetes, Type 2 Diabetes 1,287 views For many patients with obesity-related osteoarthritis, daily movement can feel like walking with a heavy backpack that never comes off

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Why it matters: Dehydration worsens constipation, fatigue, and can be dangerous if you're also experiencing vomiting or diarrhea

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The cleanest way around these study biases is randomized trials, which by design make comparison groups alike from the start