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Companies discontinued agents such as liraglutide and Albiglutide, while the approval of combination therapies such as liraglutide/insulin degludec highlights the role of GLP-1 receptor agonists in diabetes and obesity management (23)(25)

Altissimi G, Salviati M, Turchetta R, et al

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10.1152/ajpheart.00646.2012 106

For example, if a 2 mg dose is taken: After 1 week: ~1 mg remains After 2 weeks: ~0.5 mg remains After 34 weeks: Levels continue to decrease until fully cleared This extended presence contributes to its effectiveness and allows for weekly dosing without sharp fluctuations in blood concentration